优化的激素刺激对于产生有活力的胚胎以及随后的着床至关重要。

Optimized hormonal stimulation is critical for production of viable embryos and establishment of subsequent implantation.

作者信息

Tao Tao, Robichaud Alfred, Nadeau Sylvie, Savoie Rejean, Gallant Bernard, Ouellette Rodney J

机构信息

Conceptia Reproductive Clinic, Beausejour Medical Research Institute, Georges-L.-Dumont Hospital, Moncton, Canada.

出版信息

J Assist Reprod Genet. 2006 Jan;23(1):23-8. doi: 10.1007/s10815-005-9005-1. Epub 2006 Jan 4.

DOI:10.1007/s10815-005-9005-1

PMID:16395538

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3455430/

Abstract

PURPOSE

To investigate the effects of follicle number and size at the time of hCG administration, and ovarian stimulation length on the outcome of in vitro fertilization and pregnancy rate.

METHODS

During the ovarian stimulation regimen, the follicular number and size were determined by transvaginal ultrasonographic examination. Ovulation was induced as early as three or more follicles were at least 16 mm in their greatest diameter.

RESULTS

The fertilization rates were significantly increased with the longer length of stimulation (10-12 days: 75.4% and 13-16 days: 83.2%). However, no significant differences in the chemical pregnancy, clinical pregnancy, and implantation rates were found between 10-12 days (53.7%, 43.9%, and 21.8%) and 13-16 days (50.0%, 43.8%, and 23.4%) of stimulation. There were no significant differences in fertilization and chemical pregnancy rates between two groups with > or = and <18 follicles in the ovaries on the day of hCG (human chorionic gonadotrophin) administration. However, the clinical pregnancy and implantation rates (47.2% and 26.0%) in the group with <18 follicles were significantly higher than those (33.3% and 15.5%) in the group with > or =18 follicles, respectively.

CONCLUSIONS

Excessive and rapid ovarian stimulation appears to decrease the survival of embryos at later stages after transfer. The advantage of prolonged stimulation may outweigh the potential adverse effects in some patients.

摘要

目的

探讨人绒毛膜促性腺激素（hCG）注射时卵泡数量和大小以及卵巢刺激时长对体外受精结局和妊娠率的影响。

方法

在卵巢刺激方案实施期间，通过经阴道超声检查确定卵泡数量和大小。当至少有三个卵泡最大直径达到或超过16毫米时，尽早诱导排卵。

结果

随着刺激时长增加（10 - 12天：75.4%；13 - 16天：83.2%），受精率显著提高。然而，刺激10 - 12天（化学妊娠率53.7%、临床妊娠率43.9%、着床率21.8%）和13 - 16天（化学妊娠率50.0%、临床妊娠率43.8%、着床率23.4%）之间，在化学妊娠、临床妊娠和着床率方面未发现显著差异。在hCG注射当天，卵巢中卵泡数≥18个和＜18个的两组之间，受精率和化学妊娠率无显著差异。然而，卵泡数＜18个组的临床妊娠率（47.2%）和着床率（26.0%）分别显著高于卵泡数≥18个组（33.3%和15.5%）。