Arria Amelia M, Derauf Chris, Lagasse Linda L, Grant Penny, Shah Rizwan, Smith Lynne, Haning William, Huestis Marilyn, Strauss Arthur, Della Grotta Sheri, Liu Jing, Lester Barry
Center for Substance Abuse Research, University of Maryland, College Park, Maryland, USA.
Matern Child Health J. 2006 May;10(3):293-302. doi: 10.1007/s10995-005-0052-0. Epub 2006 Jan 5.
Methamphetamine use is a continuing problem in several regions of the United States and yet few studies have focused on prenatal methamphetamine exposure. The purpose of this study was to estimate the prevalence and correlates of alcohol, tobacco, and other substance use-including methamphetamine-during pregnancy.
The sample consisted of the first 1632 eligible mothers who consented to participate in a large-scale multisite study focused on prenatal methamphetamine exposure. This unselected screening sample included both users and nonusers of alcohol, tobacco, methamphetamine, and other drugs. Substance use was determined by maternal self-report and/or GC/MS confirmation of a positive meconium screen.
Overall, 5.2% of women used methamphetamine at some point during their pregnancy. One quarter of the sample smoked tobacco, 22.8% drank alcohol, 6.0% used marijuana, and 1.3% used barbiturates prenatally. Less than 1% of the sample used heroin, benzodiazepines, and hallucinogens. Multivariate modeling results showed that tobacco smokers and illicit drug users were more likely to be single and less educated, have attended less than 11 prenatal visits, and utilize public financial assistance.
This is the first large-scale investigation to report the prevalence of methamphetamine use during pregnancy in areas of the United States where methamphetamine is a notable concern. Follow-up research is ongoing to investigate the outcomes associated with prenatal methamphetamine exposure. Given that this research extends and confirms previous findings showing that high-risk groups of pregnant women can be identified on the basis of basic demographic characteristics, targeted interventions are greatly needed to reduce serious adverse outcomes associated with prenatal alcohol and tobacco use.
在美国的几个地区,使用甲基苯丙胺仍是一个持续存在的问题,但很少有研究关注孕期甲基苯丙胺暴露情况。本研究的目的是估计孕期酒精、烟草及其他物质(包括甲基苯丙胺)使用的患病率及其相关因素。
样本包括前1632名同意参与一项关注孕期甲基苯丙胺暴露的大规模多地点研究的合格母亲。这个未经过筛选的样本包括酒精、烟草、甲基苯丙胺及其他药物的使用者和非使用者。物质使用情况通过母亲自我报告和/或胎粪筛查呈阳性的气相色谱/质谱确认来确定。
总体而言,5.2%的女性在孕期的某个阶段使用过甲基苯丙胺。四分之一的样本吸烟,22.8%饮酒,6.0%使用大麻,1.3%在产前使用巴比妥类药物。样本中使用海洛因、苯二氮卓类药物和致幻剂的比例不到1%。多变量建模结果显示,吸烟者和非法药物使用者更可能单身、受教育程度较低、产前检查次数少于11次,并使用公共财政援助。
这是首次在美国甲基苯丙胺问题较为突出的地区进行的大规模调查,报告孕期甲基苯丙胺使用的患病率。后续研究正在进行,以调查与孕期甲基苯丙胺暴露相关的后果。鉴于本研究扩展并证实了先前的研究结果,即可以根据基本人口统计学特征识别高危孕妇群体,因此迫切需要有针对性的干预措施,以减少与孕期酒精和烟草使用相关的严重不良后果。