Department of Pharmaceutical Sciences, Marshall University School of Pharmacy, Huntington, WV, USA.
Department of Biomedical Sciences, Marshall University School of Medicine, Huntingotn, WV, USA.
Biochem Cell Biol. 2023 Jun 1;101(3):198-203. doi: 10.1139/bcb-2022-0349. Epub 2023 Feb 10.
Methamphetamine is one of the most commonly used illicit drugs during pregnancy. Most studies investigating the impact of maternal use of methamphetamine on children have focused on neurological outcomes. In contrast, cardiovascular outcomes in these children have not been characterized. Recent studies in rodents provide evidence that prenatal exposure to methamphetamine induces changes in cardiac gene expression, changes in the heart's susceptibility to ischemic injury, and changes in vascular function that may increase the risk of developing cardiovascular disorders later in life. Importantly, these changes are sex-dependent. This review summarizes our current understanding of how methamphetamine use during pregnancy impacts the cardiovascular function of adult offspring and highlights gaps in our knowledge of the potential cardiovascular risks associated with prenatal exposure to methamphetamine.
甲基苯丙胺是孕妇最常使用的非法药物之一。大多数研究调查了母体使用甲基苯丙胺对儿童的影响，这些研究主要集中在神经学结果上。相比之下，这些儿童的心血管结果尚未得到明确。最近在啮齿动物中的研究提供了证据，表明产前暴露于甲基苯丙胺会导致心脏基因表达的改变、心脏对缺血性损伤的敏感性改变以及血管功能的改变，这些改变可能会增加日后患心血管疾病的风险。重要的是，这些变化是具有性别依赖性的。本综述总结了我们目前对怀孕期间使用甲基苯丙胺如何影响成年后代心血管功能的理解，并强调了我们对与产前暴露于甲基苯丙胺相关的潜在心血管风险的认识存在差距。
