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Bovine babesiosis: failure to induce interferon gamma production in response to Babesia bovis antigens in cattle.

作者信息

Orinda G O, Gale K R, Wright I G, Parrodi F

机构信息

CSIRO, Division of Tropical Animal Production, Indooroopilly, Queensland, Australia.

出版信息

Int J Parasitol. 1992 May;22(3):395-8. doi: 10.1016/s0020-7519(05)80020-7.

Abstract

The immune response to Babesia bovis infection or vaccination was evaluated by measuring antibody and interferon gamma (IFN-gamma) production to protective recombinant and crude native B. bovis antigens. Cells from vaccinated or infected cattle failed to produce detectable IFN-gamma when stimulated with B. bovis antigens in vitro. In contrast, antibody was induced by protective recombinant B. bovis antigens. These findings are consistent with the argument that immunity to B. bovis infection is correlated most strongly with humoral rather than cell-mediated immune responses.

摘要

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