Brown W C, Norimine J, Goff W L, Suarez C E, McElwain T F
Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, WA 99164-7040, USA.
Parasite Immunol. 2006 Jul;28(7):315-27. doi: 10.1111/j.1365-3024.2006.00849.x.
Babesial parasites infect cattle in tropical and temperate regions of the world and cause significant morbidity and mortality. Discovery of protective antigens that could be used in a killed vaccine has been slow and to date there are few promising vaccine candidates for cattle Babesia. This review describes mechanisms of protective innate and adaptive immune responses to babesial parasites and different strategies to identify potentially protective protein antigens of B. bovis, B. bigemina, and B. divergens. Successful parasites often cause persistent infection, and this paper also discusses how B. bovis evades and regulates the immune response to promote survival of parasite and host. Development of successful non-living recombinant vaccines will depend on increased understanding of protective immune mechanisms and availability of parasite genomes.
巴贝斯虫寄生虫感染世界热带和温带地区的牛，会导致严重的发病和死亡。能够用于灭活疫苗的保护性抗原的发现进展缓慢，迄今为止，针对牛巴贝斯虫几乎没有有前景的候选疫苗。这篇综述描述了针对巴贝斯虫寄生虫的先天性和适应性免疫保护反应机制，以及鉴定牛巴贝斯虫、双芽巴贝斯虫和分歧巴贝斯虫潜在保护性蛋白质抗原的不同策略。成功的寄生虫通常会导致持续性感染，本文还讨论了牛巴贝斯虫如何逃避和调节免疫反应以促进寄生虫和宿主的存活。成功的非活性重组疫苗的开发将取决于对保护性免疫机制的深入理解以及寄生虫基因组的可得性。
