Dufouil Carole, Alpérovitch Annick
INSERM Unité 708, hôpital La Salpêtrière, 75651 Paris.
Rev Prat. 2005 Nov 15;55(17):1869-78.
Because of global ageing of the population, the occurrence of Alzheimer's disease (AD) cases is increasing dramatically and AD is becoming a major public health preoccupation. By the year 2020, the World Health Organisation predicts that there will be almost 29 millions demented people throughout the world, two third of them being AD cases. This dramatic perspective could only be modified with new curative treatments or prevention. These last years, there is increasing evidence from epidemiological studies for the role of vascular risk factors in the aetiology of AD among which hypertension, type 2 diabetes, or high cholesterol. These potentially modifiable risk factors raise hope for prevention of Alzheimer's disease.
由于全球人口老龄化,阿尔茨海默病(AD)病例的发生率正在急剧上升,AD正成为主要的公共卫生问题。世界卫生组织预测,到2020年,全球将有近2900万痴呆症患者,其中三分之二为AD病例。只有通过新的治疗方法或预防措施才能改变这一严峻的局面。近年来,越来越多的流行病学研究证据表明血管危险因素在AD病因中发挥作用,其中包括高血压、2型糖尿病或高胆固醇。这些潜在的可改变危险因素为预防阿尔茨海默病带来了希望。