Alyahya Ghassan Ayish, Hietanen Jaana, Heegaard Steffen, Kivelä Tero, Prause Jan Ulrik
Eye Pathology Institute, University of Copenhagen, Copenhagen, Denmark.
Acta Ophthalmol Scand. 2005 Dec;83(6):711-5. doi: 10.1111/j.1600-0420.2005.00513.x.
To compare the frequency of exfoliation syndrome (EXS) in Denmark and Finland in eyes enucleated for absolute glaucoma and uveal melanoma and to correlate these results to reported clinical prevalence rates.
The material consisted of 304 and 39 eyes consecutively removed because of absolute glaucoma and of 240 and 149 eyes enucleated because of uveal melanoma in Denmark and Finland, respectively. Histological sections of all eyes were stained with haematoxylin-eosin and periodic acid-Schiff and examined under a light microscope for EXS. Diagnosis of EXS was made by the consensus of the investigators.
In absolute glaucoma eyes, EXS was observed in 12 out of 304 eyes (3.9%, 95% CI 2.1-6.8) in Denmark, and in 16 out of 39 eyes (41%, 95% CI 26-58) in Finland (p < 0.0001). In the melanoma eyes, EXS was noted in two out of 240 eyes (0.8%, 95% CI 0.1-3.0) in Denmark and in nine out of 149 eyes (6.0%, 95% CI 2.8-11) (p < 0.0037) in Finland.
The frequency of EXS was significantly higher in eyes removed for absolute glaucoma and malignant melanoma in Finland than in Denmark. This supports the clinical impression that EXS is rare in Denmark compared to other Nordic countries.
比较丹麦和芬兰因绝对期青光眼和葡萄膜黑色素瘤而摘除眼球中剥脱综合征（EXS）的发生率，并将这些结果与已报道的临床患病率相关联。
该研究材料分别包括丹麦的304只和芬兰的39只因绝对期青光眼而连续摘除的眼球，以及丹麦的240只和芬兰的149只因葡萄膜黑色素瘤而摘除的眼球。所有眼球的组织学切片均用苏木精-伊红和过碘酸-希夫染色，并在光学显微镜下检查是否存在EXS。EXS的诊断由研究人员共同确定。
在因绝对期青光眼摘除的眼球中，丹麦304只眼球中有12只（3.9%，95%可信区间2.1 - 6.8）观察到EXS，芬兰39只眼球中有16只（41%，95%可信区间26 - 58）（p < 0.0001）。在因黑色素瘤摘除的眼球中，丹麦240只眼球中有2只（0.8%，95%可信区间0.1 - 3.0）观察到EXS，芬兰149只眼球中有9只（6.0%，95%可信区间2.8 - 11）（p < 0.0037）。
芬兰因绝对期青光眼和恶性黑色素瘤而摘除眼球中EXS的发生率显著高于丹麦。这支持了与其他北欧国家相比EXS在丹麦较为罕见的临床印象。
