Gutmann David H, Maher Elizabeth A, Van Dyke Terry
Department of Neurology, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
Cancer Res. 2006 Jan 1;66(1):10-3. doi: 10.1158/0008-5472.CAN-05-3180.
Nervous system tumors are clinically challenging neoplasms that form within the central and peripheral nervous system. Although there have been many clinical trials using novel agents for the treatment of primary brain tumors, there have been few advances that positively affect overall patient survival. Over the past several years, there has been significant progress in the development of accurate small-animal spontaneous brain tumor models, small-animal neuroimaging, and tools for the bioinformatic analysis of complex molecular data sets, all of which have contributed to an improved understanding of the pathogenesis of human brain tumors. Whereas these models will continue to be of great value in basic science investigations, they can also be used to identify and validate potential therapies for brain tumors and to evaluate these drugs in preclinical trials. The National Cancer Institute recently convened a workshop to review the current state of small-animal brain tumor modeling and to make recommendations about the use of these models to improve the clinical outcome for patients with brain tumors. In this meeting report, we outline the current state of small-animal models for brain tumors, the potential applications of these models, and the recommendations made by the workshop participants for the use of mouse models in the preclinical evaluation of potential brain tumor therapies.
神经系统肿瘤是在中枢和周围神经系统内形成的具有临床挑战性的肿瘤。尽管已经有许多使用新型药物治疗原发性脑肿瘤的临床试验，但在积极影响患者总体生存率方面进展甚微。在过去几年中，精确的小动物自发性脑肿瘤模型、小动物神经成像以及用于复杂分子数据集生物信息分析的工具取得了重大进展，所有这些都有助于增进对人脑肿瘤发病机制的理解。虽然这些模型在基础科学研究中仍将具有巨大价值，但它们也可用于识别和验证脑肿瘤的潜在疗法，并在临床前试验中评估这些药物。美国国家癌症研究所最近召开了一次研讨会，以审查小动物脑肿瘤建模的现状，并就使用这些模型改善脑肿瘤患者的临床结局提出建议。在本会议报告中，我们概述了小动物脑肿瘤模型的现状、这些模型的潜在应用以及研讨会参与者就使用小鼠模型进行潜在脑肿瘤疗法临床前评估提出的建议。
