Hruban Ralph H, Adsay N Volkan, Albores-Saavedra Jorge, Anver Miriam R, Biankin Andrew V, Boivin Gregory P, Furth Emma E, Furukawa Toru, Klein Alison, Klimstra David S, Kloppel Gunter, Lauwers Gregory Y, Longnecker Daniel S, Luttges Jutta, Maitra Anirban, Offerhaus G Johan A, Pérez-Gallego Lucía, Redston Mark, Tuveson David A
Department of Pathology, The Sol Goldman Center for Pancreatic Cancer Research, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21231, USA.
Cancer Res. 2006 Jan 1;66(1):95-106. doi: 10.1158/0008-5472.CAN-05-2168.
Several diverse genetically engineered mouse models of pancreatic exocrine neoplasia have been developed. These mouse models have a spectrum of pathologic changes; however, until now, there has been no uniform nomenclature to characterize these changes. An international workshop, sponsored by The National Cancer Institute and the University of Pennsylvania, was held from December 1 to 3, 2004 with the goal of establishing an internationally accepted uniform nomenclature for the pathology of genetically engineered mouse models of pancreatic exocrine neoplasia. The pancreatic pathology in 12 existing mouse models of pancreatic neoplasia was reviewed at this workshop, and a standardized nomenclature with definitions and associated images was developed. It is our intention that this nomenclature will standardize the reporting of genetically engineered mouse models of pancreatic exocrine neoplasia, that it will facilitate comparisons between genetically engineered mouse models and human pancreatic disease, and that it will be broad enough to accommodate newly emerging mouse models of pancreatic neoplasia.
已经开发出几种不同的胰腺外分泌肿瘤基因工程小鼠模型。这些小鼠模型有一系列病理变化；然而，到目前为止，还没有统一的命名法来描述这些变化。由美国国立癌症研究所和宾夕法尼亚大学主办的一次国际研讨会于2004年12月1日至3日举行，目的是为胰腺外分泌肿瘤基因工程小鼠模型的病理学建立一个国际公认的统一命名法。本次研讨会回顾了12种现有的胰腺肿瘤小鼠模型中的胰腺病理学，并制定了带有定义和相关图像的标准化命名法。我们的目的是，这种命名法将使胰腺外分泌肿瘤基因工程小鼠模型的报告标准化，将有助于基因工程小鼠模型与人类胰腺疾病之间的比较，并且其范围足够广泛，能够适应新出现的胰腺肿瘤小鼠模型。
