音调诱导的仓鼠耳蜗静纤毛损伤与暴露水平和持续时间的关系。

Tone-induced stereocilia lesions as a function of exposure level and duration in the hamster cochlea.

作者信息

Kaltenbach J A, Schmidt R N, Kaplan C R

机构信息

Department of Audiology, Wayne State University, School of Medicine, Detroit, Michigan 48201.

出版信息

Hear Res. 1992 Jul;60(2):205-15. doi: 10.1016/0378-5955(92)90022-f.

DOI:10.1016/0378-5955(92)90022-f

PMID:1639730

Abstract

The present study presents an atlas of the effects of 10 kHz tone exposures of different levels and durations on cochlear hair cells and their stereocilia in the Syrian golden hamster. Animals were sound exposed while under anesthesia. The exposure conditions were varied over an intensity range of 90-129 dB SPL; at the highest levels (126-129 dB SPL) the exposure periods were varied over a range of 30 min to 4 h. In animals with mild damage the lesions were commonly restricted to either the inner hair cells and/or the first row of outer hair cells; the order of damage susceptibility was IHC, OHC1, OHC2, OHC3. Damage to the second and third rows of outer hair cells were found only in animals with the severest lesions. Possible mechanisms underlying the row-specific distributions of these lesions and relative susceptibilities of the 4 rows of hair cells are discussed.

摘要

本研究展示了不同强度和时长的10千赫兹纯音暴露对叙利亚金仓鼠耳蜗毛细胞及其静纤毛影响的图谱。动物在麻醉状态下接受声音暴露。暴露条件在90 - 129分贝声压级的强度范围内变化；在最高水平（126 - 129分贝声压级），暴露时长在30分钟至4小时的范围内变化。在轻度损伤的动物中，病变通常局限于内毛细胞和/或第一排外毛细胞；损伤易感性顺序为内毛细胞、第一排外毛细胞、第二排外毛细胞、第三排外毛细胞。仅在损伤最严重的动物中发现第二排和第三排外毛细胞受损。讨论了这些病变的排特异性分布以及4排毛细胞相对易感性背后的可能机制。