Matsumoto Koji, Yasugi Toshiharu, Oki Akinori, Fujii Takuma, Nagata Chisato, Sekiya Souei, Hoshiai Hiroshi, Taketani Yuji, Kanda Tadahito, Kawana Takashi, Yoshikawa Hiroyuki
Department of Obstetrics and Gynecology, University of Tokyo, Tokyo 113-8655, Japan.
Cancer Lett. 2006 Jan 18;231(2):309-13. doi: 10.1016/j.canlet.2005.02.023.
To identify the predictive markers for spontaneous regression of cervical intraepithelial neoplasia (CIN), we examined whether IgG antibody responses to common human papillomavirus (HPV) L1-capsids correlate with CIN regression. In a cohort study, a total of 116 Japanese women with CIN grade I/II were tested for cervical HPV DNA and serum IgG antibodies to HPV16/52/58/6 L1-capsids. Our data suggest that baseline IgG reactivities to HPV L1-capsids do not serve as a predictive marker of CIN regression, in contrast to histological CIN grades and HPV DNA status.
为了确定宫颈上皮内瘤变（CIN）自发消退的预测标志物，我们研究了针对常见人乳头瘤病毒（HPV）L1衣壳的IgG抗体反应是否与CIN消退相关。在一项队列研究中，对总共116名患有I/II级CIN的日本女性进行了宫颈HPV DNA检测以及针对HPV16/52/58/6 L1衣壳的血清IgG抗体检测。我们的数据表明，与组织学CIN分级和HPV DNA状态不同，基线时针对HPV L1衣壳的IgG反应性并不能作为CIN消退的预测标志物。
