Anisimov Vladimir N, Berstein Lev M, Popovich Irina G, Zabezhinski Mark A, Egormin Peter A, Tyndyk Margarita L, Anikin Ivan V, Semenchenko Anna V, Yashin Anatoli I
N.N. Petrov Research Institute of Oncology, St. Petersburg 197758, Russia.
Ann N Y Acad Sci. 2005 Dec;1057:220-34. doi: 10.1196/annals.1356.017.
Studies in mammals have led to the suggestion that hyperglycemia and hyperinsulinemia are important factors both in aging and in the development of cancer. Insulin/insulin-like growth factor 1 (IGF-1) signaling molecules linked to longevity include DAF-2 and insulin receptor (InR) and their homologues in mammals and to inactivation of the corresponding genes followed by increased life span in nematodes, fruit flies, and mice. It is possible that the life-prolonging effect of caloric restriction are due to decreasing IGF-1 levels. A search of pharmacological modulators of life span-extending mutations in the insulin/IGF-1 signaling pathway and mimetics of effects of caloric restriction could be a direction in the regulation of longevity. Some literature and our own observations suggest that antidiabetic drugs could be promising candidates for both life span extension and prevention of cancer.
对哺乳动物的研究表明，高血糖和高胰岛素血症是衰老和癌症发展中的重要因素。与长寿相关的胰岛素/胰岛素样生长因子1（IGF-1）信号分子包括DAF-2和胰岛素受体（InR）及其在哺乳动物中的同源物，在相应基因失活后，线虫、果蝇和小鼠的寿命会延长。热量限制的寿命延长作用可能是由于IGF-1水平降低。寻找胰岛素/IGF-1信号通路中延长寿命突变的药理调节剂以及热量限制作用的模拟物可能是调节寿命的一个方向。一些文献和我们自己的观察表明，抗糖尿病药物可能是延长寿命和预防癌症的有前途的候选药物。
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