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Metformin for aging and cancer prevention.
Aging (Albany NY). 2010 Nov;2(11):760-74. doi: 10.18632/aging.100230.
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The key role of growth hormone-insulin-IGF-1 signaling in aging and cancer.
Crit Rev Oncol Hematol. 2013 Sep;87(3):201-23. doi: 10.1016/j.critrevonc.2013.01.005. Epub 2013 Feb 21.
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Metformin: do we finally have an anti-aging drug?
Cell Cycle. 2013 Nov 15;12(22):3483-9. doi: 10.4161/cc.26928. Epub 2013 Oct 24.
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Insulin/IGF-1 signaling pathway driving aging and cancer as a target for pharmacological intervention.
Exp Gerontol. 2003 Oct;38(10):1041-9. doi: 10.1016/s0531-5565(03)00169-4.
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Metformin slows down aging and extends life span of female SHR mice.
Cell Cycle. 2008 Sep 1;7(17):2769-73. doi: 10.4161/cc.7.17.6625. Epub 2008 Sep 11.

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The combination of metformin and high glucose increased longevity of a DAF-16/FOXO-independent manner: cancer/diabetic model via .
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Lipid and glucose metabolism in senescence.
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Metformin: A Review of Potential Mechanism and Therapeutic Utility Beyond Diabetes.
Drug Des Devel Ther. 2023 Jun 26;17:1907-1932. doi: 10.2147/DDDT.S409373. eCollection 2023.
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Therapeutic Antiaging Strategies.
Biomedicines. 2022 Oct 8;10(10):2515. doi: 10.3390/biomedicines10102515.
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Recent Neurotherapeutic Strategies to Promote Healthy Brain Aging: Are we there yet?
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A Comparative Study of the Lipophilicity of Metformin and Phenformin.
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本文引用的文献

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[Effect of metformin on the magnitude of oxidative stress in patients with type 2 diabetes mellitus].
Probl Endokrinol (Mosk). 2007 Feb 15;53(1):3-7. doi: 10.14341/probl20075313-7.
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Metformin prevents tobacco carcinogen--induced lung tumorigenesis.
Cancer Prev Res (Phila). 2010 Sep;3(9):1066-76. doi: 10.1158/1940-6207.CAPR-10-0055. Epub 2010 Sep 1.
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Metformin and other biguanides in oncology: advancing the research agenda.
Cancer Prev Res (Phila). 2010 Sep;3(9):1060-5. doi: 10.1158/1940-6207.CAPR-10-0175. Epub 2010 Sep 1.
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Obesity, hyperinsulinemia and breast cancer: novel targets and a novel role for metformin.
Expert Rev Mol Diagn. 2010 May;10(4):509-19. doi: 10.1586/erm.10.22.
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Metformin, independent of AMPK, inhibits mTORC1 in a rag GTPase-dependent manner.
Cell Metab. 2010 May 5;11(5):390-401. doi: 10.1016/j.cmet.2010.03.014.

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