Tat'ianenko L V, Lavretskaia Z F, Raĭkhman L M, Moshkovskii Iu S, Lebedeva O I
Vopr Med Khim. 1976 May-Jun;22(3):406-10.
In sarcoplasmic reticulum of rabbit skeletal muscles the activity of Ca2+, Mg2+- dependent ATPase was distinctly inhibited under effect of neuroleptic drugs - derivatives of phenothiazine and butyrophenone. The effect of tricyclic antidepressants was less pronounced. Tranquilizers (derivatives of 1,4-benzodiazepine) inhibited the enzyme, but trioxazin was only slightly active. High concentrations of lithium salts and of psychostimulants caffeine and corasole were found to stimulate the Ca2+, Mg2+-ATPase activity; low concentrations of the substances slightly inhibited the enzyme. The blocking effect of psychotropic drugs was more distinct, if the enzyme preparations were previously treated with ATP.
在兔骨骼肌的肌浆网中，抗精神病药物（吩噻嗪和丁酰苯的衍生物）的作用下，Ca2+、Mg2+依赖的ATP酶活性明显受到抑制。三环类抗抑郁药的作用则不太明显。镇静剂（1,4-苯二氮䓬的衍生物）抑制该酶，但三恶嗪只有轻微活性。发现高浓度的锂盐以及精神兴奋药咖啡因和可拉佐可刺激Ca2+、Mg2+-ATP酶活性；低浓度的这些物质对该酶有轻微抑制作用。如果酶制剂预先用ATP处理，精神药物的阻断作用会更明显。
