膜增生性肾小球肾炎合并糖尿病肾病
Membranoproliferative glomerulonephritis complicating diabetic nephropathy.
作者信息
Grcevska L, Petrusevska G, Dzikova S, Kostadinova S, Polenaković M
机构信息
Department of Nephrology, Clinical Center Skopje, R. Macedonia.
出版信息
Prilozi. 2005 Dec;26(2):53-61.
BACKGROUND
Renal diseases other than diabetic nephropathy can be found in diabetic patients who have undergone renal biopsy. Various forms of primary and secondary glomerular diseases were reported, but membranoproliferative glomerulonephritis was rare.
METHODS
Analyzing data at our Department for the past three years, we noted 18 patients with primary membranoproliferative glomerulonephritis and 4 associated with diabetic nephropathy.
RESULTS
Nodular glomerulosclerosis with diffuse membranoproliferative glomerulonephritis was registered in two patients and a diffuse form of diabetic nephropathy with a combination of segmental and diffuse changes characteristic of membranoproliferative glomerulonephritis in the other two patients.
CONCLUSIONS
Analyzing what can be common for these two diseases we can conclude that they are at least three disorders: 1. hyperperfusion injury, hallmark for the diabetic nephropathy, but also with the highest incidence in membranoproliferative glomerulonephritis than in the other glomerulonephritides; 2. mesangial matrix expansion, and; 3. thickening of all extracellular membranes.
背景
在接受肾活检的糖尿病患者中可发现除糖尿病肾病之外的其他肾脏疾病。已报道了各种形式的原发性和继发性肾小球疾病，但膜增生性肾小球肾炎较为罕见。
方法
分析我们科室过去三年的数据，我们注意到18例原发性膜增生性肾小球肾炎患者以及4例合并糖尿病肾病的患者。
结果
两名患者出现结节性肾小球硬化伴弥漫性膜增生性肾小球肾炎，另外两名患者出现弥漫性糖尿病肾病，伴有膜增生性肾小球肾炎特征性的节段性和弥漫性改变。
结论
分析这两种疾病的共同之处，我们可以得出结论，它们至少有三种病症：1. 高灌注损伤，这是糖尿病肾病的标志，但在膜增生性肾小球肾炎中的发生率也高于其他肾小球肾炎；2. 系膜基质扩张；3. 所有细胞外膜增厚。
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