Cohen J T, Gil Z, Fliss D M
Department of Otolaryngology Head and Neck Surgery, Sourasky Medical Center, Tel Aviv University, Tel Aviv, Israel.
Harefuah. 2005 Dec;144(12):826-9, 912.
Laryngopharyngeal reflux (LPR) refers to the backflow of stomach contents into the throat. Patients with LPR suffer from hoarseness, throat discomfort, dysphonia, chronic cough, chronic throat clearing and dysphagia. In 2001 Koufman et al. published the self-administered nine-item reflux symptom index (RSI) to assist clinicians in detecting and documenting the presence of LPR. This instrument appears to be valid and highly reproducible.
To develop the Hebrew version of the Reflux Symptom Index (RSI).
Validation of the Hebrew questionnaire included translation of the original instrument from English to Hebrew by three independent translators and retranslation back from Hebrew to English by three other translators. In the United States, patients completed the original and back-translated questionnaires. Scores correlation of the two instruments was performed using correlation coefficient analysis. Validation of the questionnaire was performed by measuring the association between the mean RSI score and the reflux findings upon flexible endoscopy. A control group of 9 patients with no clinical signs of reflux was chosen for our outpatient clinic.
A total of '14 patients in the United States completed the original and the back-translated questionnaires. The correlation coefficient (r) was 0.92 (p < 0.001). In the second part of the study. 21 consistent Israeli patients that were referred to our voice center because of voice problems were requested to complete the questionnaire. History and endoscopic examinations did not reveal tumors, paralysis, functional voice problems or smoking. The mean age was 53 years (range 37-69 years). There were 14 women in the study group. Twenty patients had RSI higher then 10 (considered positive to the presence of reflux disease). Examination of the larynx demonstrated presence of reflux (e.g. edema of the vocal cords, posterior commissure hypertrophy, arythenoids edema, subglottic edema) in 19 cases (90.5% of patients). All the patients in the control group had a RSI lower then 10.
The Hebrew RSI is an easy self-administered and reliable instrument that can help the clinician detect patients suffering from LPR and monitor their treatment.
喉咽反流（LPR）是指胃内容物反流至咽喉部。喉咽反流患者会出现声音嘶哑、咽喉不适、发声困难、慢性咳嗽、习惯性清嗓及吞咽困难等症状。2001年，科夫曼等人发表了自我管理的九项反流症状指数（RSI），以帮助临床医生检测和记录喉咽反流的存在。该工具似乎有效且具有高度可重复性。
开发反流症状指数（RSI）的希伯来语版本。
希伯来语问卷的验证包括由三名独立翻译人员将原始工具从英语翻译成希伯来语，再由另外三名翻译人员从希伯来语回译成英语。在美国，患者完成了原始问卷和回译问卷。使用相关系数分析对两种工具的得分进行相关性分析。通过测量平均RSI得分与软性内镜检查时反流结果之间的关联来进行问卷验证。从我们的门诊中选择了9名无反流临床体征的患者作为对照组。
在美国，共有14名患者完成了原始问卷和回译问卷。相关系数（r）为0.92（p < 0.001）。在研究的第二部分，21名因声音问题转诊至我们嗓音中心的以色列患者被要求完成问卷。病史和内镜检查未发现肿瘤、麻痹、功能性嗓音问题或吸烟情况。平均年龄为53岁（范围37 - 69岁）。研究组中有14名女性。20名患者的RSI高于10（被认为存在反流疾病）。喉镜检查显示19例（90.5%的患者）存在反流（如声带水肿、后联合肥大、杓状软骨水肿、声门下水肿）。对照组所有患者的RSI均低于10。
希伯来语RSI是一种易于自我管理且可靠的工具，可以帮助临床医生检测喉咽反流患者并监测其治疗情况。
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