[海南鹰爪茎中生物碱的研究]
[Studies on the alkaloids from stem of Artabotrys hainanensis].
作者信息
Han Chang-ri, Zhu Guo-yuan, Chen Guang-ying, Zhang Han-yang, Bi He-ping, Fang Hong-xun
机构信息
Department of Chemistry, Hainan Normal University, Haikou 571158, China.
出版信息
Zhongguo Zhong Yao Za Zhi. 2005 Nov;30(21):1660-2.
OBJECTIVE
To investigate the alkaloids from the stem of Artabotrys hainanensis.
METHOD
Compounds in plant extracts were separated by silica gel and sephadex LH-20 column chromatography. Chemical structures were elucidated by chemical and spectral analyses including UV, 1H-NMR, 13C-NMR, ESIMS and ESI-MS-MS.
RESULT
Eight alkaloids were isolated and identified as spinosine (1), 3-hydroxynornuciferine (2), juzirine (3), artabotrine (4), liridine (5), assimilobine (6), isococlaurine (7), N-demethylarmepavine (8).
CONCLUSION
All alkaloids were isolated from this plant for the first time and compounds 1, 3, 7 and 8 were isolated from genus Artabotrys for the first time.
目的
研究海南鹰爪花茎中的生物碱。
方法
采用硅胶柱色谱和葡聚糖凝胶LH - 20柱色谱对植物提取物中的化合物进行分离。通过紫外光谱（UV）、氢核磁共振谱（1H - NMR）、碳核磁共振谱（13C - NMR）、电喷雾离子化质谱（ESIMS）和电喷雾串联质谱（ESI - MS - MS）等化学和光谱分析方法对化学结构进行鉴定。
结果
分离鉴定出8种生物碱，分别为多穗柯碱（1）、3 - 羟基去甲南天竹碱（2）、爪哇灵（3）、海南鹰爪花碱（4）、鹅掌楸碱（5）、去甲荷叶碱（6）、异紫堇定碱（7）、N - 去甲基阿朴啡碱（8）。
结论
所有生物碱均首次从该植物中分离得到，化合物1、3、7和8首次从鹰爪花属植物中分离得到。
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