Lopez-Meza Elmer, Corona-Vazquez Teresa, Ruano-Calderon Luis A, Ramirez-Bermudez Jesus
Department of Neurology, National Institute of Neurology and Neurosurgery, Mexico City, Mexico.
Psychiatry Clin Neurosci. 2005 Dec;59(6):739-42. doi: 10.1111/j.1440-1819.2005.01446.x.
Severe impulsiveness in the absence of apparent neurological signs has rarely been reported as a clinical presentation of multiple sclerosis (MS). An 11-year-old female developed progressive and sustained personality disturbances including disinhibition, hypersexuality, drug abuse, aggressiveness and suicide attempts, without neurological signs. She was given several unsuccessful psychopharmacological and psychotherapeutic interventions. At age 21, a diagnosis of MS was made, confirmed by imaging, laboratory and neurophysiological studies. Although unusual, MS may produce pure neurobehavioral disturbances. In the present case, widespread demyelinization produced a complex behavioral disorder, with features compatible with orbitofrontal and Klüver-Bucy syndromes.
在没有明显神经体征的情况下出现严重冲动行为，作为多发性硬化症（MS）的临床表现鲜有报道。一名11岁女性出现了进行性且持续的人格障碍，包括行为抑制解除、性欲亢进、药物滥用、攻击性及自杀企图，但无神经体征。她接受了多次心理药物治疗和心理治疗干预，均未成功。21岁时，经影像学、实验室及神经生理学检查确诊为MS。虽然罕见，但MS可能会导致单纯的神经行为障碍。在本病例中，广泛的脱髓鞘病变引发了一种复杂的行为障碍，其特征与眶额综合征和克吕弗-布西综合征相符。
