Moore S C, Anderson S J, Walker W S
Department of Immunology, St. Jude Children's Research Hospital, Memphis, Tennessee 38101-0318.
J Leukoc Biol. 1992 Jul;52(1):128-9. doi: 10.1002/jlb.52.1.128.
Mouse macrophages do not express CD4 on their surfaces. We used the polymerase chain reaction to investigate CD4 gene transcription in individual clones of primary mouse splenic macrophages and cell lines of spleen and bone marrow macrophages. The results show only the presence of CD4 mRNA transcripts that are truncated in the 3' coding sequence, thus explaining the lack of expression of a mature CD4 gene product by these cells.
小鼠巨噬细胞表面不表达CD4。我们运用聚合酶链反应来研究原代小鼠脾脏巨噬细胞的各个克隆以及脾脏和骨髓巨噬细胞系中的CD4基因转录情况。结果显示仅存在3'编码序列截短的CD4 mRNA转录本，从而解释了这些细胞缺乏成熟CD4基因产物表达的原因。
