Kuwabara S, Misawa S, Kanai K, Kikkawa Y, Nishimura M, Nakaseko C, Cho R K, Hattori T
Department of Neurology, Chiba University School of Medicine, Japan.
Neurology. 2006 Jan 10;66(1):105-7. doi: 10.1212/01.wnl.0000188757.38495.23.
Polyneuropathy, organomegaly, endocrinopathy, M-protein, and skin changes syndrome is a rare multisystem disorder. Overproduction of vascular endothelial growth factor (VEGF) by plasmocytoma could be responsible for the symptoms. The authors treated four patients with high-dose chemotherapy and autologous peripheral blood stem cell transplantation. Within 6 months, symptoms associated with rapid normalization of serum VEGF levels improved.
多神经病、器官肿大、内分泌病、M蛋白血症和皮肤改变综合征是一种罕见的多系统疾病。浆细胞瘤过度产生血管内皮生长因子（VEGF）可能是导致这些症状的原因。作者对4例患者进行了大剂量化疗和自体外周血干细胞移植治疗。在6个月内，与血清VEGF水平迅速恢复正常相关的症状得到改善。
