Piazza O, Cotena S, Esposito G, De Robertis E, Tufano R
Anesthesiology and Resuscitation Unit, University of Naples II, Naples, Italy.
Minerva Chir. 2005 Dec;60(6):477-80.
The aim of this study was to compare serum S100B levels and EEG findings as prognostic indexes in comatose (GCS<8) patients after cardiac arrest.
S100B serum levels were assessed 12 h after the event and EEG findings were recorded within 24 h in comatose cardiac arrest survivors. At hospital discharge, patients were divided into groups according the Glasgow-outcome scale (GOS): group 1 with bad neurological outcome and group 2 with good neurological outcome (GOS 4-5). S100B levels and EEG findings were retrospectively tested about their predictive value.
S100B has a very low specificity (37.5%) while S100B sensitivity is 100%. EEG findings specificity is 75% and sensitivity 50%. S100B was not significantly lower in patients who recovered consciousness (10 patients) and there was no significant difference in EEGs findings between group 1 and 2.
The association of serum S100B levels with EEG might be helpful when used together to formulate outcome in comatose patients within 24 h after cardiac arrest. However, increased levels of S100B 12 h after a cardiac arrest might be expression of a still amendable brain damage.
本研究旨在比较血清S100B水平和脑电图结果，作为心脏骤停后昏迷（格拉斯哥昏迷评分<8分）患者的预后指标。
在事件发生12小时后评估血清S100B水平，并在昏迷的心脏骤停幸存者24小时内记录脑电图结果。出院时，根据格拉斯哥预后量表（GOS）将患者分为两组：1组为神经功能预后不良组，2组为神经功能预后良好组（GOS 4 - 5分）。回顾性检验S100B水平和脑电图结果的预测价值。
S100B特异性非常低（37.5%），而S100B敏感性为100%。脑电图结果特异性为75%，敏感性为50%。意识恢复的患者（10例）血清S100B水平无显著降低，1组和2组脑电图结果无显著差异。
血清S100B水平与脑电图结果联合应用可能有助于在心脏骤停后24小时内的昏迷患者中制定预后。然而，心脏骤停12小时后S100B水平升高可能是仍可改善的脑损伤的表现。
