Colquhoun David
Department of Pharmacology, University College London, Gower Street, London WC1E 6BT.
Br J Pharmacol. 2006 Jan;147 Suppl 1(Suppl 1):S17-26. doi: 10.1038/sj.bjp.0706502.
This paper looks at ion channels as an example of the pharmacologist's stock in trade, the action of an agonist on a receptor to produce a response. Looked at in this way, ion channels have been helpful because they are still the only system which is simple enough for quantitative investigation of transduction mechanisms. A short history is given of attempts to elucidate what happens between the time when agonist first binds, and the time when the channel opens.
本文以离子通道为例,探讨药理学家的常用手段,即激动剂作用于受体以产生反应。从这个角度来看,离子通道很有用,因为它们仍然是唯一足够简单、可用于定量研究转导机制的系统。本文简要介绍了为阐明从激动剂首次结合到通道打开这段时间内所发生的情况而进行的尝试。