细胞因子信号转导抑制因子3（SOCS3）的常见多态性与正常女性双胞胎的体重、胰岛素敏感性或血脂水平无关。
Common polymorphisms in SOCS3 are not associated with body weight, insulin sensitivity or lipid profile in normal female twins.
作者信息
Jamshidi Y, Snieder H, Wang X, Spector T D, Carter N D, O'Dell S D
机构信息
Department of Clinical Developmental Sciences, St George's, University of London, London, UK.
出版信息
Diabetologia. 2006 Feb;49(2):306-10. doi: 10.1007/s00125-005-0093-3. Epub 2006 Jan 10.
Abstract
AIMS/HYPOTHESIS: Inhibition of signal transduction by suppressor of cytokine signalling-3 (SOCS-3) potentially influences resistance to insulin and leptin. The aim of this study was to test the association between three single-nucleotide polymorphisms (SNPs) representative of common linkage disequilibrium clusters in SOCS3 (rs4969169, rs12953258 and rs8064821) and obesity measures, insulin sensitivity measures and serum lipids in the general population.
METHODS
The three SNPs, which had rare allele frequencies >0.06, were genotyped in 2,777 female twins of European extraction (mean age 47.4+/-12.5 years) from the St Thomas' UK Adult Twin Registry (Twins UK).
RESULTS
Minor allele frequencies were as follows: rs4969169=0.067, rs12953258=0.097 and rs8064821=0.101. Individual SOCS3 SNPs were not associated with general or central obesity, or with two indices of insulin sensitivity (homeostasis model assessment and insulin sensitivity measure).
CONCLUSIONS/INTERPRETATION: The results do not indicate that any of the three SNPs studied are associated with obesity, insulin measures or lipid measures.
摘要
目的/假设：细胞因子信号转导抑制因子3（SOCS-3）对信号转导的抑制作用可能会影响机体对胰岛素和瘦素的抵抗。本研究旨在检测代表SOCS3常见连锁不平衡簇的三个单核苷酸多态性（SNP，rs4969169、rs12953258和rs8064821）与普通人群肥胖指标、胰岛素敏感性指标及血脂之间的关联。
方法
对来自英国圣托马斯成人双胞胎登记处（Twins UK）的2777名欧洲裔女性双胞胎（平均年龄47.4±12.5岁）进行基因分型，这三个SNP的罕见等位基因频率均>0.06。
结果
次要等位基因频率如下：rs4969169 = 0.067，rs12953258 = 0.097，rs8064821 = 0.101。单个SOCS3 SNP与全身或中心性肥胖，或与两种胰岛素敏感性指标（稳态模型评估和胰岛素敏感性测量）均无关联。
结论/解读：结果表明所研究的三个SNP均与肥胖、胰岛素指标或血脂指标无关。
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