Fogelholm R, Nuutila M, Vuorela A L
Department of Neurology, Central Hospital of Central Finland, Jyväskylä.
J Neurol Neurosurg Psychiatry. 1992 Jul;55(7):546-52. doi: 10.1136/jnnp.55.7.546.
The age and sex specific incidence rates, the case fatality rates, and the functional outcome of patients with primary intracerebral haemorrhage occurring in a population of 116,000 during a period of four years four months are presented. A total of 158 patients were identified, the diagnosis was confirmed in 78% by CT, and in 22% by necropsy. The crude annual incidence rate was 31/100,000 population, the age specific rates increased from two to 222/100,000 from the age of 30-39 to over 80 years. Men had higher incidence rates between the ages of 40 and 79 years. The short term case fatality rate was high, 27% of patients dying during the first day after onset of symptoms, and 50% were dead at 30 days. After the first month the probability of survival did not differ from an age- and sex-matched average population. Large haematoma volume had an adverse effect on the short term, old age (greater than 70 years) on the long term survival. Ventricular extension, especially when combined with hydrocephalus was a bad omen for short term survival. Infratentorial and large basal ganglionic haematomas, and primary intraventricular haemorrhage carried a worse prognosis than haematomas of other locations. At the end of a median 32 month follow up 55 (35%) of the patients were alive, 51% of these were independent in activities of daily living, 45% were dependent on outside help, and 4% needed constant nursing care. Old age (greater than 70 years), but not the haematoma volume or location, was associated with a poor functional recovery.
本文呈现了在四年零四个月期间,116,000人群中发生的原发性脑出血患者的年龄和性别特异性发病率、病死率以及功能转归情况。共识别出158例患者,78%通过CT确诊,22%通过尸检确诊。粗年发病率为31/100,000人口,年龄特异性发病率从30 - 39岁的2/100,000增加到80岁以上的222/100,000。40至79岁男性发病率较高。短期病死率较高,27%的患者在症状发作后第一天死亡,30天时50%死亡。第一个月后,生存概率与年龄和性别匹配的平均人群无差异。血肿量大对短期有不良影响,老年(大于70岁)对长期生存有不良影响。脑室扩展,尤其是合并脑积水时对短期生存是不祥之兆。幕下和基底节区大血肿以及原发性脑室出血的预后比其他部位血肿更差。在中位32个月随访结束时,55例(35%)患者存活,其中51%日常生活活动独立,45%依赖外界帮助,4%需要持续护理。老年(大于70岁)而非血肿量或部位与功能恢复不良相关。