Kanen B L J, Perenboom R M
VU Medisch Centrum, Postbus 7057, 1007 MB Amsterdam.
Ned Tijdschr Geneeskd. 2005 Dec 24;149(52):2893-6.
A 46-year-old man with multiple sclerosis had severe generalised pain for which treatment with paracetamol, ibuprofen, gabapentin and methyl-prednisolone had been unsuccessful. In addition normocytic anaemia without haemolysis and with a normal iron load was found. Due to bright red rectal blood loss and nausea, vomiting, weight loss, anorexia, abdominal pain and constipation a colonoscopy was planned. However, before this was performed, manual slide differentiation of a blood smear showed basophilic stippling and it turned out that the patient had been taking Ayurvedic medication up to one month before presentation. A moderately severe lead intoxication was diagnosed: 0.77 mg/l. The herbal medication had a very high lead content. The patient was successfully treated with the oral lead chelator 23-dimercaptosuccinic acid. Traditional and folk remedies often are important causes of lead poisoning.
一名46岁的多发性硬化症男性患者患有严重的全身性疼痛,使用对乙酰氨基酚、布洛芬、加巴喷丁和甲基泼尼松龙治疗均未成功。此外,还发现了无溶血且铁负荷正常的正细胞性贫血。由于鲜红色的直肠失血以及恶心、呕吐、体重减轻、厌食、腹痛和便秘,计划进行结肠镜检查。然而,在进行结肠镜检查之前,血涂片的手工玻片鉴别显示有嗜碱性点彩,结果发现该患者在就诊前一个月一直在服用阿育吠陀药物。诊断为中度严重铅中毒:0.77mg/l。这种草药药物的铅含量非常高。该患者通过口服铅螯合剂2,3-二巯基琥珀酸成功治愈。传统和民间疗法常常是铅中毒的重要原因。