Blumberg Hilary P, Fredericks Carolyn, Wang Fei, Kalmar Jessica H, Spencer Linda, Papademetris Xenophon, Pittman Brian, Martin Andres, Peterson Bradley S, Fulbright Robert K, Krystal John H
Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06511, USA.
Bipolar Disord. 2005 Dec;7(6):570-6. doi: 10.1111/j.1399-5618.2005.00264.x.
Abnormalities in volumes of the amygdala have been reported previously in adolescents and adults with bipolar disorder (BD). Several studies have reported reduced volumes in adolescents with BD; however, both decreases and increases in volumes have been reported in adults with BD. Understanding of potential developmental contributions to these disturbances in morphology of the amygdala has been limited by the absence of longitudinal data in persons with BD. Here we use a within-subject longitudinal design to investigate whether amygdala volume abnormalities persist in adolescents and young adults with BD over a time interval of approximately 2 years.
Participants included 18 adolescents and young adults: 10 participants with BD I and 8 healthy comparison participants. Amygdala volumes were measured on high-resolution magnetic resonance imaging scans acquired twice for each subject over intervals of approximately 2 years. Amygdala volumes were the dependent measures in a mixed-model statistical analysis to compare amygdala volumes between groups over time while covarying for total brain volume.
Amygdala volumes were significantly smaller in adolescents and young adults with BD compared with healthy participants (p = 0.018). The effect of time was not significant.
Although the sample size is modest, this study provides preliminary evidence to support the presence of decreased amygdala volumes in adolescents and young adults with BD that persist during this developmental epoch.
先前已有报道称，双相情感障碍（BD）青少年和成年人的杏仁核体积存在异常。多项研究报告了BD青少年的杏仁核体积减小；然而，BD成年人的杏仁核体积既有减小的情况，也有增大的情况。由于缺乏BD患者的纵向数据，对这些杏仁核形态紊乱的潜在发育影响的了解受到了限制。在此，我们采用受试者内纵向设计，以研究BD青少年和青年成年人在大约2年的时间间隔内杏仁核体积异常是否持续存在。
参与者包括18名青少年和青年成年人：10名BD-I患者和8名健康对照参与者。在大约2年的间隔时间内，对每个受试者进行两次高分辨率磁共振成像扫描，测量杏仁核体积。在混合模型统计分析中，杏仁核体积是相关测量指标，用于比较不同组之间随时间变化的杏仁核体积，同时对全脑体积进行协变量分析。
与健康参与者相比，BD青少年和青年成年人的杏仁核体积显著更小（p = 0.018）。时间效应不显著。
尽管样本量不大，但本研究提供了初步证据，支持BD青少年和青年成年人存在杏仁核体积减小的情况，且在这一发育阶段持续存在。
