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双相情感障碍青少年和青年成人前额叶进行性异常的初步证据。

Preliminary evidence for progressive prefrontal abnormalities in adolescents and young adults with bipolar disorder.

作者信息

Kalmar Jessica H, Wang Fei, Spencer Linda, Edmiston Erin, Lacadie Cheryl M, Martin Andrés, Constable R Todd, Duncan James S, Staib Lawrence H, Papademetris Xenophon, Blumberg Hilary P

机构信息

Department of Psychiatry, Yale School of Medicine, New Haven, Connecticut 06511, USA.

出版信息

J Int Neuropsychol Soc. 2009 May;15(3):476-81. doi: 10.1017/S1355617709090584.

DOI:10.1017/S1355617709090584
PMID:19402934
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2852397/
Abstract

Previous cross-sectional study of ventral prefrontal cortex (VPFC) implicated progressive volume abnormalities during adolescence in bipolar disorder (BD). In the present study, a within-subject, longitudinal design was implemented to examine brain volume changes during adolescence/young adulthood. We hypothesized that VPFC volume decreases over time would be greater in adolescents/young adults with BD than in healthy comparison adolescents/young adults. Eighteen adolescents/young adults (10 with BD I and 8 healthy comparison participants) underwent two high-resolution magnetic resonance imaging scans over approximately 2 years. Regional volume changes over time were measured. Adolescents/young adults with BD displayed significantly greater volume loss over time, compared to healthy comparison participants, in a region encompassing VPFC and rostral PFC and extending to rostral anterior cingulate cortex (p < .05). Additional areas where volume change differed between groups were observed. While data should be interpreted cautiously due to modest sample size, this study provides preliminary evidence to support the presence of accelerated loss in VPFC and rostral PFC volume in adolescents/young adults with BD.

摘要

先前对腹侧前额叶皮层（VPFC）的横断面研究表明，双相情感障碍（BD）患者在青春期存在渐进性的体积异常。在本研究中，采用了受试者内纵向设计来检查青春期/青年期的脑容量变化。我们假设，与健康对照青少年/青年相比，BD青少年/青年的VPFC体积随时间的减少会更大。18名青少年/青年（10名BD-I患者和8名健康对照参与者）在大约2年的时间里接受了两次高分辨率磁共振成像扫描。测量了随时间的区域体积变化。与健康对照参与者相比，BD青少年/青年在包括VPFC和喙状前额叶皮层并延伸至喙状前扣带回皮层的区域中，随时间显示出明显更大的体积损失（p <.05）。还观察到两组之间体积变化不同的其他区域。由于样本量较小，数据应谨慎解释，但本研究提供了初步证据，支持BD青少年/青年中VPFC和喙状前额叶皮层体积加速损失的存在。

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