急性早幼粒细胞白血病的治疗策略。

Strategies for the treatment of acute promyelocytic leukemia.

作者信息

Frankfurt Olga, Tallman Martin S

机构信息

Division of Hematology and Oncology, Northwestern University Feinberg School of Medicine, Robert H. Lurie Comprehensive Care Center of Northwestern University, 676 North St. Clair Street, Suite 850, Chicago, IL 60611, USA.

出版信息

J Natl Compr Canc Netw. 2006 Jan;4(1):37-50. doi: 10.6004/jnccn.2006.0005.

DOI:10.6004/jnccn.2006.0005

PMID:16403403

Abstract

The outcome of acute promyelocytic leukemia (APL) has improved dramatically during the past 40 years. Insights into the genetic and biologic mechanisms of APL lead to the development of specific and effective therapeutic strategies. This article discusses the therapeutic interventions that transformed APL from one of the most lethal leukemias to one that is highly curable.

摘要

在过去40年中，急性早幼粒细胞白血病（APL）的治疗结果有了显著改善。对APL遗传和生物学机制的深入了解促成了特定且有效的治疗策略的发展。本文讨论了那些将APL从最致命的白血病之一转变为一种高度可治愈疾病的治疗干预措施。