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将心房肺分流术转换为心外全腔静脉肺动脉连接术可改善心肺功能。

Conversion of atriopulmonary Fontan to extracardiac total cavopulmonary connection improves cardiopulmonary function.

作者信息

Giardini Alessandro, Pace Napoleone Carlo, Specchia Salvatore, Donti Andrea, Formigari Roberto, Oppido Guido, Gargiulo Gaetano, Picchio Fernando M

机构信息

Pediatric Cardiology and Adult Congenital Unit, University of Bologna, Via Massarenti 9, 40138, Bologna, Italy.

出版信息

Int J Cardiol. 2006 Nov 18;113(3):341-4. doi: 10.1016/j.ijcard.2005.11.046. Epub 2006 Jan 5.

Abstract

BACKGROUND

Experimental studies showed that extracardiac total cavopulmonary connection provides superior hemodynamics than atriopulmonary Fontan.

METHODS

We prospectively assessed the impact of conversion of atriopulmonary Fontan to extracardiac total cavopulmonary connection on exercise capacity and cardiac function in 6 consecutive patients.

RESULTS

Six months after conversion to extracardiac total cavopulmonary connection, we observed an increase in peak oxygen uptake in all patients (p=0.01;+17%). This improvement was associated to an increase of peak O(2) pulse (p=0.01;+16%), but no change in peak heart rate, arterial oxygen saturation at peak exercise, and pulmonary function. Ventricular ejection fraction did not change significantly after surgery. Conversion was associated with an improvement in heart failure symptoms as assessed by the New York Heart Association classification. Patients who had undergone additional anti-arrhythmia surgery for atrial fibrillation had no recurrence of arrhythmia at follow-up.

CONCLUSION

Data indicate that conversion to extracardiac total cavopulmonary connection is associated with an improvement of cardiopulmonary function and heart failure symptoms. Improved exercise capacity is due to an increase in O(2) pulse and may reflect an improved cardiac stroke volume after the operation.

摘要

背景

实验研究表明,心外全腔静脉肺动脉连接术比心房肺动脉Fontan手术具有更优越的血流动力学表现。

方法

我们前瞻性地评估了6例连续患者从心房肺动脉Fontan手术转换为心外全腔静脉肺动脉连接术对运动能力和心功能的影响。

结果

转换为心外全腔静脉肺动脉连接术后6个月,我们观察到所有患者的峰值摄氧量均增加(p = 0.01;增加17%)。这一改善与峰值O₂脉搏增加有关(p = 0.01;增加16%),但峰值心率、运动峰值时的动脉血氧饱和度和肺功能无变化。术后心室射血分数无显著变化。根据纽约心脏协会分类评估,转换手术与心力衰竭症状的改善有关。因心房颤动接受额外抗心律失常手术的患者在随访中无心律失常复发。

结论

数据表明,转换为心外全腔静脉肺动脉连接术与心肺功能和心力衰竭症状的改善有关。运动能力的提高归因于O₂脉搏增加,可能反映了术后心搏量的改善。

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