Schornack Sebastian, Meyer Annett, Römer Patrick, Jordan Tina, Lahaye Thomas
Institut für Genetik, Martin-Luther-Universität Halle-Wittenberg, 06099 Halle (Saale), Germany.
J Plant Physiol. 2006 Feb;163(3):256-72. doi: 10.1016/j.jplph.2005.12.001. Epub 2006 Jan 5.
Plant disease resistance (R) genes mediate specific recognition of pathogens via perception of cognate avirulence (avr) gene products. The numerous highly similar AvrBs3-like proteins from the bacterial genus Xanthomonas provide together with their corresponding R proteins a unique biological resource to dissect the molecular basis of recognition specificity. A central question in this context is if R proteins that mediate recognition of structurally similar Avr proteins are themselves functionally similar or rather dissimilar. The recent isolation of rice xa5, rice Xa27 and tomato Bs4, R genes that collectively mediate recognition of avrBs3-like genes, provides a first clue to the molecular mechanisms that plants employ to detect AvrBs3-like proteins. Their initial characterization suggests that these R proteins are structurally and functionally surprisingly diverge. This review summarizes the current knowledge on R-protein-mediated recognition of AvrBs3-like proteins and provides working models on how recognition is achieved at the molecular level.
植物抗病（R）基因通过感知同源无毒（avr）基因产物来介导对病原体的特异性识别。来自黄单胞菌属的众多高度相似的类AvrBs3蛋白及其相应的R蛋白共同提供了一种独特的生物学资源，用于剖析识别特异性的分子基础。在这种情况下，一个核心问题是，介导对结构相似的Avr蛋白进行识别的R蛋白本身在功能上是相似还是不同。最近分离出的水稻xa5、水稻Xa27和番茄Bs4这几个R基因，它们共同介导对类avrBs3基因的识别，这为植物检测类AvrBs3蛋白所采用的分子机制提供了首个线索。它们的初步特征表明，这些R蛋白在结构和功能上惊人地不同。本综述总结了目前关于R蛋白介导的对类AvrBs3蛋白识别的知识，并提供了在分子水平上如何实现识别的工作模型。
