Metcalf M G, Braiden V, Livesey J H, Wells J E
Department of Endocrinology, Princess Margaret Hospital, Christchurch, New Zealand.
J Psychosom Res. 1992 Sep;36(6):569-84. doi: 10.1016/0022-3999(92)90042-z.
What is the role of the uterus in the aetiology of the premenstrual syndrome (PMS)? Twelve women kept a daily symptom record before and after hysterectomy. Psychological and physical symptom patterns were analysed by Fourier analysis and the response to hysterectomy by maximum likelihood ANOVA. Hysterectomy was associated with a 66% reduction in mean premenstrual tension (PMT) severity for both psychological and physical symptoms (p less than 0.005). The milder symptoms appeared unrelated to post-operative changes in health or ovarian function. Seven women experienced mood-related PMT in every pre-hysterectomy cycle; the persistence of unfailing mood-related PMT in one of these women after hysterectomy suggests that her symptoms were hormonally controlled and the loss of regular PMT in the other six women suggests that a uterine factor, or psychological factors associated with the menstrual cycle were implicated. We conclude that a uterus is not essential for the expression of PMT, but that its removal often results in the amelioration of symptoms.
子宫在经前综合征（PMS）的病因学中起什么作用？12名女性在子宫切除术前和术后记录每日症状。通过傅里叶分析对心理和身体症状模式进行分析，并通过最大似然方差分析对子宫切除术的反应进行分析。子宫切除术与心理和身体症状的平均经前紧张（PMT）严重程度降低66%相关（p小于0.005）。较轻的症状似乎与术后健康或卵巢功能的变化无关。7名女性在每次子宫切除术前的周期中都经历与情绪相关的PMT；其中一名女性在子宫切除术后持续出现与情绪相关的PMT，这表明她的症状受激素控制，而其他6名女性不再有规律的PMT，这表明存在子宫因素或与月经周期相关的心理因素。我们得出结论，子宫对于PMT的表现并非必不可少，但切除子宫通常会导致症状改善。
