Powles T, Savage P, Short D, Young A, Pappin C, Seckl M J
Department of Health Charing Cross Gestational Trophoblastic Disease Centre, Hammersmith Hospitals Campus of Imperial College London, Palace Rd, London W68RF, UK.
Br J Cancer. 2006 Jan 16;94(1):51-4. doi: 10.1038/sj.bjc.6602899.
The significance of residual lung metastasis from malignant gestational trophoblastic neoplasm (GTN) after the completion of chemotherapy is unknown. We currently do not advocate resection of these masses. Here, we investigate the outcome of these patients. Patients with residual lung abnormalities after the completion of treatment for GTN were compared to those who had a complete radiological resolution of the disease. None of the residual masses post-treatment were surgically removed. In all, 76 patients were identified. Overall 53 (70%) patients had no radiological abnormality on CXR or CT after completion of treatment. Eight (11%) patients had residual disease on CXR alone 15 patients had residual disease on CT (19%). During follow-up, two patients (2.6%) relapsed. One of these had had a complete radiological response post-treatment whereas the other had residual disease on CT. Patients with residual lung lesions after completing treatment for GTN do not appear to have an increased chance of relapse compared to those with no residual abnormality. We continue to recommend that these patients do not require pulmonary surgery for these lesions.
化疗结束后，恶性妊娠滋养细胞肿瘤（GTN）残留肺转移灶的意义尚不清楚。我们目前不主张切除这些肿块。在此，我们对这些患者的预后进行研究。将GTN治疗结束后肺部仍有异常的患者与疾病在影像学上完全缓解的患者进行比较。治疗后所有残留肿块均未进行手术切除。总共确定了76例患者。总体而言，53例（70%）患者在治疗结束后胸部X线片（CXR）或计算机断层扫描（CT）上无影像学异常。8例（11%）患者仅在CXR上有残留病灶，15例（19%）患者在CT上有残留病灶。在随访期间，2例患者（2.6%）复发。其中1例患者治疗后影像学完全缓解，而另1例患者CT上有残留病灶。与无残留异常的患者相比，GTN治疗结束后肺部有残留病灶的患者复发几率似乎并未增加。我们继续建议这些患者无需针对这些病灶进行肺部手术。
