脑室周围白质软化症特别影响皮层对生物运动的脑磁图反应。
Periventricular leukomalacia specifically affects cortical MEG response to biological motion.
作者信息
Pavlova Marina, Marconato Fabio, Sokolov Alexander, Braun Christoph, Birbaumer Niels, Krägeloh-Mann Ingeborg
机构信息
Department of Paediatric Neurology and Child Development, Children's Hospital, University of Tübingen Medical School, Tübingen, Germany.
出版信息
Ann Neurol. 2006 Feb;59(2):415-9. doi: 10.1002/ana.20762.
OBJECTIVE
Periventricular leukomalacia (PVL) underlies most of the neurological morbidity including visual-perceptual deficits in survivors of premature birth. However, it is unknown whether and, if so, how PVL affects functional cortical activity.
METHODS
Here, we assessed changes in the magnetoencephalographic (MEG) response to visual displays depicting human locomotion in adolescents who were born premature with magnetic resonance imaging signs of PVL.
RESULTS
Dynamics of MEG activity parallel behavioral deficits. Early (140-170 milliseconds) brain activation over the right parietal cortex was weaker in patients compared with term-born controls.
INTERPRETATION
This is the first evidence for stimulus-specific modulation of cortical activity by periventricular lesions providing new insights into the functional pathology of PVL.
目的
脑室周围白质软化（PVL）是大多数神经功能障碍的基础，包括早产幸存者的视觉感知缺陷。然而，PVL是否以及如何影响功能性皮质活动尚不清楚。
方法
在此，我们评估了患有PVL磁共振成像征象的早产青少年对描绘人类运动的视觉显示的脑磁图（MEG）反应变化。
结果
MEG活动动态与行为缺陷平行。与足月出生的对照组相比，患者右侧顶叶皮质的早期（140 - 170毫秒）脑激活较弱。
解读
这是脑室周围病变对皮质活动进行刺激特异性调节的首个证据，为PVL的功能病理学提供了新见解。
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