Waites Anthony B, Briellmann Regula S, Saling Michael M, Abbott David F, Jackson Graeme D
Brain Research Institute, Austin Health, Heidelberg West, Victoria, Australia.
Ann Neurol. 2006 Feb;59(2):335-43. doi: 10.1002/ana.20733.
Functional connectivity maps the distributed network of brain regions fluctuating synchronously during a continuous brain state. This study sought to investigate whether patients with left temporal lobe epilepsy (TLE) differ from controls in their resting-state functional connectivity between typical language regions.
We studied 17 patients with left TLE, together with eight healthy controls, using seeded functional connectivity. Seed regions were defined using the regions of maximal activation and deactivation during a language functional magnetic resonance imaging (fMRI) task in a separate cohort of 30 controls.
Language fMRI produced the expected activation pattern, which was not different between patients and controls. However, functional connectivity between language areas during rest was markedly different; whereas controls showed connectivity between each of the seed areas and the majority of the language areas, patients showed connectivity only with a few areas, particularly the seed area itself. This difference was significant in the direct comparison of patients and control connectivity maps.
We suggest that this reduced connectivity in left temporal lobe epilepsy may reflect a disturbance of the language network during resting state in patients and may be related to subtle language difficulties in this patient population.
功能连接描绘了在持续脑状态下同步波动的脑区分布式网络。本研究旨在调查左颞叶癫痫（TLE）患者在典型语言区域之间的静息态功能连接是否与对照组存在差异。
我们使用种子功能连接研究了17例左颞叶癫痫患者以及8名健康对照。种子区域是在另一组30名对照的语言功能磁共振成像（fMRI）任务期间，根据最大激活和失活区域来定义的。
语言功能磁共振成像产生了预期的激活模式，患者和对照之间没有差异。然而，静息期间语言区域之间的功能连接明显不同；对照组显示每个种子区域与大多数语言区域之间存在连接，而患者仅与少数区域存在连接，特别是种子区域本身。在患者和对照连接图的直接比较中，这种差异具有显著性。
我们认为左颞叶癫痫中这种连接性降低可能反映了患者静息状态下语言网络的紊乱，并且可能与该患者群体中细微的语言困难有关。
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