Cyr Christopher, Holubecki Ania M, Shi Lingxiao, Lakshman Maya, Salvo Joseph J, Anderson Nathan L, Kragel James E, Lurie Sarah M, Voss Joel, Kokkinos Vasileios, Rosenow Joshua, Schuele Stephan U, Johnson Elizabeth L, Zelano Christina, Braga Rodrigo M
Ken & Ruth Davee Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Department of Neurology, University of Chicago, Chicago, IL, USA.
bioRxiv. 2025 Aug 4:2025.07.31.667730. doi: 10.1101/2025.07.31.667730.
Intracranial electrical stimulation (ES) is routinely used therapeutically, diagnostically, and to provide causal evidence in neuroscience studies. However, our understanding of the brain network-level effects of ES remains limited. We applied precision functional mapping (PFM), based on functional magnetic resonance imaging (fMRI), to define large-scale networks within individual epilepsy patients. We show that single-pulse electrical stimulation (SPES) and high-frequency electrical stimulation (HFES) are more likely to evoke within-network responses and elicit network-related behavioral effects, respectively, when applied near to a PFM-defined network region. Network-level effects were more likely when stimulating sites in white matter, in close proximity to the targeted network, and within a region predominantly occupied by the targeted network. Further, network-specific modulation may be achievable by applying lower current intensities at these sites. Our findings support that modulation of specific networks is achievable by targeting ES to a functional anatomic "sweet spot" that can be identified using PFM.
颅内电刺激（ES）通常用于治疗、诊断以及在神经科学研究中提供因果证据。然而，我们对ES在脑网络水平上的影响的理解仍然有限。我们应用基于功能磁共振成像（fMRI）的精准功能映射（PFM）来定义个体癫痫患者的大规模网络。我们发现，当在PFM定义的网络区域附近施加单脉冲电刺激（SPES）和高频电刺激（HFES）时，它们分别更有可能引发网络内反应并产生与网络相关的行为效应。当刺激部位位于白质、靠近目标网络且在主要由目标网络占据的区域内时，更有可能产生网络水平的效应。此外，通过在这些部位施加较低的电流强度，可能实现特定网络的调制。我们的研究结果支持，通过将电刺激靶向到可以使用PFM识别的功能解剖“最佳点”，可以实现对特定网络的调制。
