Pongchaiyakul Choowong, Pongchaiyakul Chatlert, Pratipanawatr Thongchai
Division of Nursing Cardiology, Srinagarind Hospital, Khon Kaen, Thailand.
J Med Assoc Thai. 2005 Aug;88(8):1092-7.
Dyslipidemia is an important, modifiable CHD risk factor. Previous studies have reported the prevalence of dyslipidemia particularly in urban populations. However, its prevalence in rural Northeast Thailand has not been well documented since extensive dietary and lifestyle transitions induced by the rapid socio-economic development of the late 1990s and early 2000s. The authors, therefore, conducted a cross-sectional assessment for the prevalence of dyslipidemia among rural Thais (in Khon Kaen province) using the National Cholesterol Education Program (NCEP) Adult Treatment Panel (ATP III) Guidelines. The 325 subjects recruited (136 men; 189 women) averaged 53.8 +/- 17.6 years of age (range, 20-88). After having the subjects fast 12 hours, serum samples were collected. Total cholesterol, triglycerides, low-density lipoprotein (LDL-C) and high-density lipoprotein (HDL-C) cholesterols were measured. The prevalence of hypercholesterolemia (> 200 mg/dL), hypertriglyceridemia (> 150 mg/dL), high LDL-C (> 130 mg/dL) and low HDL-C (< 40 mg/dL) was 31, 40, 20 and 14 per cent, respectively. Women had a 2- to 3.5-fold higher prevalence of hypercholesterolemia and high LDL-C than men, while the prevalence of hypertriglyceridemia was comparable. The prevalence of dyslipidemia increased with advancing age and increasing BMI; notwithstanding, a high prevalence of dyslipidemia was observed in the youngest tertile as well. In conclusion, the present study demonstrated a high prevalence of dyslipidemia in rural Thai adults; consequently, primary lipid screening should be considered for all ages.
血脂异常是一个重要的、可改变的冠心病危险因素。以往研究报告了血脂异常的患病率,尤其是在城市人群中。然而,自20世纪90年代末和21世纪初社会经济快速发展引发广泛的饮食和生活方式转变以来,泰国东北部农村地区血脂异常的患病率尚未得到充分记录。因此,作者使用美国国家胆固醇教育计划(NCEP)成人治疗小组(ATP III)指南,对泰国农村地区(孔敬省)人群的血脂异常患病率进行了横断面评估。招募的325名受试者(136名男性;189名女性)平均年龄为53.8±17.6岁(范围为20-88岁)。让受试者禁食12小时后,采集血清样本。测量总胆固醇、甘油三酯、低密度脂蛋白(LDL-C)和高密度脂蛋白(HDL-C)胆固醇。高胆固醇血症(>200mg/dL)、高甘油三酯血症(>150mg/dL)、高LDL-C(>130mg/dL)和低HDL-C(<40mg/dL)的患病率分别为31%、40%、20%和14%。女性高胆固醇血症和高LDL-C的患病率比男性高2至3.5倍,而高甘油三酯血症的患病率相当。血脂异常的患病率随着年龄的增长和体重指数的增加而升高;尽管如此,在最年轻的三分位数人群中也观察到了高血脂异常患病率。总之,本研究表明泰国农村成年人血脂异常的患病率很高;因此,应考虑对所有年龄段进行初级血脂筛查。