Kuznetsov V I, Iushchuk N D, Morrison V V
Klin Med (Mosk). 2005;83(11):49-52.
The subjects of the study--patients with severe hemorrhagic fever with renal syndrome--were divided into two groups: those who were on hemodialysis, and those who were not. The study included evaluation of the phospholipid spectrum of erythrocyte membranes in the acute period and during recovery. The results revealed conformational shifts in the structure of the bilipid membrane layer, which were maximal during the acute phase of the disease, as well as less prominent and varied changes in the phospholipid spectrum during recovery. This allows determination of the terms of rehabilitation of the patients and substantiates administration of membrane stabilizers as a part of complex therapy of residual syndrome.
该研究的对象——重症肾综合征出血热患者——被分为两组:进行血液透析的患者和未进行血液透析的患者。该研究包括对急性期和恢复期红细胞膜磷脂谱的评估。结果显示,双脂膜层结构发生构象变化,在疾病急性期变化最大,而在恢复期磷脂谱变化不太显著且多样。这有助于确定患者的康复期限,并证实使用膜稳定剂作为残余综合征综合治疗的一部分是合理的。