Kim K M, Kogan B A, Massad C A
Department of Urology, University of California School of Medicine, San Francisco 94143-0738.
J Urol. 1992 Aug;148(2 Pt 2):497-502. doi: 10.1016/s0022-5347(17)36639-9.
The pathophysiology of fetal urinary obstruction has not been elucidated. Using a unique, reproducible and easily reversible animal preparation, we studied the acute hemodynamic and endocrinological responses to partial fetal bladder obstruction in 16 ovine fetuses at 115 days of gestation (term 147 days). After partial obstruction blood pressure and renal weight increased significantly for at least 72 hours. Renal blood flow trended upwards, particularly from 24 to 72 hours, although this change was not statistically significant. Plasma renin activity was significantly increased during the first 24 hours after obstruction but it returned to baseline thereafter. Plasma cortisol or catecholamine concentrations remained unchanged. The time course and pattern of hemodynamic changes in this fetal sheep preparation of partial urinary obstruction differ significantly from those reported in other preparations.
胎儿尿路梗阻的病理生理学尚未阐明。我们使用一种独特、可重复且易于逆转的动物模型，研究了妊娠115天（足月为147天）的16只绵羊胎儿在部分膀胱梗阻后的急性血流动力学和内分泌反应。部分梗阻后，血压和肾脏重量至少在72小时内显著增加。肾血流量呈上升趋势，尤其是在24至72小时之间，尽管这一变化无统计学意义。梗阻后最初24小时内血浆肾素活性显著增加，但随后恢复至基线水平。血浆皮质醇或儿茶酚胺浓度保持不变。这种部分尿路梗阻的绵羊胎儿模型中血流动力学变化的时间进程和模式与其他模型报道的显著不同。
