Voskoboinik Ilia, Trapani Joseph A
Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
Immunol Cell Biol. 2006 Feb;84(1):66-71. doi: 10.1111/j.1440-1711.2005.01409.x.
Perforin is a cytolytic protein stored in secretory granules of CTL and NK cells. It synergizes with proapoptotic serine proteases, granzymes, to deliver the lethal hit to virus-infected or transformed target cells. The mechanism of perforin action has not been described beyond its original characterization in the 1980s, and its role in human disease has remained elusive. This article addresses recent key advances in genetic, clinical and biochemical studies that have reignited the current interest in perforin biology.
穿孔素是一种储存在细胞毒性T淋巴细胞（CTL）和自然杀伤细胞（NK细胞）分泌颗粒中的溶细胞蛋白。它与促凋亡丝氨酸蛋白酶颗粒酶协同作用，对病毒感染或转化的靶细胞给予致命一击。自20世纪80年代对穿孔素作用的最初描述以来，其作用机制尚未得到进一步阐述，它在人类疾病中的作用也一直难以捉摸。本文阐述了遗传学、临床和生化研究方面的最新关键进展，这些进展重新点燃了当前对穿孔素生物学的兴趣。
