Ito Kiyoshi, Utsunomiya Hiroki, Suzuki Takashi, Saitou Sumika, Akahira Jun-Ichi, Okamura Kunihiro, Yaegashi Nobuo, Sasano Hironobu
Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, Sendai, Japan.
Mol Cell Endocrinol. 2006 Mar 27;248(1-2):136-40. doi: 10.1016/j.mce.2005.11.038. Epub 2006 Jan 6.
In situ estrogen metabolism and synthesis have been considered to play a very important role in the development and progression of human endometrial carcinoma. 17Beta-hydroxysteroid dehydrogenases (17-HSDs) are enzymes involved in the formation of active sex steroids, including testosterone, estrone (E1) and estradiol (E2). Estrogens are interchanged by two enzymes, 17-HSD types 1 and 2, type 1 converts E1 to E2, and type 2 does reverse actions. 17-HSD type 5 catalyzes the reduction of androstenedione to testosterone. 17-HSD type 2 expression was decreased through normal endometrium, hyperplasia and carcinoma accordingly. There was a significant inverse correlation between intratumoral E2 concentration and the level of 17-HSD type 2 mRNA in endometrial carcinoma. 17-HSD type 5 expression was significantly increased through normal endometrium, hyperplasia and carcinoma accordingly. These results indicated that 17-HSD types 2 and 5 play an important role in the regulation of in situ estrogen production in endometrial carcinoma.
原位雌激素代谢与合成被认为在人类子宫内膜癌的发生和发展中起着非常重要的作用。17β-羟基类固醇脱氢酶（17-HSDs）是参与活性甾体激素形成的酶，包括睾酮、雌酮（E1）和雌二醇（E2）。雌激素由1型和2型17-HSD这两种酶进行转换，1型将E1转化为E2，2型则起相反作用。5型17-HSD催化雄烯二酮还原为睾酮。2型17-HSD的表达在正常子宫内膜、增生和癌组织中依次降低。子宫内膜癌组织内E2浓度与2型17-HSD mRNA水平之间存在显著负相关。5型17-HSD的表达在正常子宫内膜、增生和癌组织中依次显著增加。这些结果表明，2型和5型17-HSD在子宫内膜癌原位雌激素产生的调节中起重要作用。
