McCurdy Richard D, Féron François, Perry Chris, Chant David C, McLean Duncan, Matigian Nick, Hayward Nicholas K, McGrath John J, Mackay-Sim Alan
Eskitis Institute for Cell and Molecular Therapies, Griffith University, Brisbane, QLD 4111, Australia.
Schizophr Res. 2006 Feb 28;82(2-3):163-73. doi: 10.1016/j.schres.2005.10.012. Epub 2006 Jan 6.
We previously demonstrated that olfactory cultures from individuals with schizophrenia had increased cell proliferation compared to cultures from healthy controls. The aims of this study were to (a) replicate this observation in a new group of individuals with schizophrenia, (b) examine the specificity of these findings by including individuals with bipolar I disorder and (c) explore gene expression differences that may underlie cell cycle differences in these diseases. Compared to controls (n = 10), there was significantly more mitosis in schizophrenia patient cultures (n = 8) and significantly more cell death in the bipolar I disorder patient cultures (n = 8). Microarray data showed alterations to the cell cycle and phosphatidylinositol signalling pathways in schizophrenia and bipolar I disorder, respectively. Whilst caution is required in the interpretation of the array results, the study provides evidence indicating that cell proliferation and cell death in olfactory neuroepithelial cultures is differentially altered in schizophrenia and bipolar disorder.
我们之前证明，与健康对照者的培养物相比，精神分裂症患者的嗅觉培养物中细胞增殖增加。本研究的目的是：（a）在一组新的精神分裂症患者中重复这一观察结果；（b）纳入I型双相情感障碍患者以检验这些发现的特异性；（c）探索可能是这些疾病中细胞周期差异基础的基因表达差异。与对照组（n = 10）相比，精神分裂症患者培养物（n = 8）中有明显更多的有丝分裂，I型双相情感障碍患者培养物（n = 8）中有明显更多的细胞死亡。微阵列数据分别显示精神分裂症和I型双相情感障碍中细胞周期和磷脂酰肌醇信号通路的改变。虽然在解释阵列结果时需要谨慎，但该研究提供的证据表明，嗅觉神经上皮培养物中的细胞增殖和细胞死亡在精神分裂症和双相情感障碍中存在差异改变。
