Brüggemann Holger, Cazalet Christel, Buchrieser Carmen
Unité de Génomique des Microorganismes Pathogènes and CNRS URA 2171, Institut Pasteur, 28 Rue du Dr Roux, 75724 Paris, France.
Curr Opin Microbiol. 2006 Feb;9(1):86-94. doi: 10.1016/j.mib.2005.12.009. Epub 2006 Jan 6.
The intracellular pathogen Legionella pneumophila has evolved sophisticated mechanisms that enable it to subvert host functions, enter, survive and replicate in amoebae or alveolar macrophages, and to finally evade these hosts. Protozoa are essential for the growth of Legionella and the interaction with amoeba seems to be the driving force in the evolution of its pathogenicity. This is reflected in the genome of this pathogen, which encodes a high number and variety of eukaryotic-like proteins that are able to interfere in the various steps of the infectious cycle by mimicking functions of eukaryotic proteins. Central to the pathogenicity of L. pneumophila are the many secretion systems delivering these and other effectors to the host cell. Recent studies have highlighted the multi-functional role of these factors secreted by L. pneumophila, in host-pathogen interactions.
细胞内病原体嗜肺军团菌已经进化出复杂的机制，使其能够破坏宿主功能，进入变形虫或肺泡巨噬细胞并在其中存活和繁殖，最终逃避这些宿主。原生动物对于军团菌的生长至关重要，与变形虫的相互作用似乎是其致病性进化的驱动力。这在该病原体的基因组中得到体现，该基因组编码大量且多样的类真核蛋白，这些蛋白能够通过模拟真核蛋白的功能干扰感染周期的各个步骤。嗜肺军团菌致病性的核心是众多分泌系统，这些系统将这些效应蛋白和其他效应因子传递到宿主细胞。最近的研究强调了嗜肺军团菌分泌的这些因子 在宿主-病原体相互作用中的多功能作用。
