van Cleef Koen W R, Smit Martine J, Bruggeman Cathrien A, Vink Cornelis
Department of Medical Microbiology, Cardiovascular Research Institute Maastricht (CARIM), University of Maastricht, P.O. Box 5800, 6202 AZ Maastricht, The Netherlands.
J Clin Virol. 2006 Mar;35(3):343-8. doi: 10.1016/j.jcv.2005.10.013. Epub 2006 Jan 6.
Cytomegaloviruses (CMVs) have developed various sophisticated strategies to manipulate and evade the defense mechanisms of their hosts. Among the CMV genes that are predicted to be involved in these strategies are genes that encode mimics of cellular proteins, such as G protein-coupled receptors (GPCRs) and chemokines (CKs). These genes may have been pirated from the host genome during the long co-evolution of virus and host.
In this report, the putative functions of the CMV-encoded homologs of GPCRs and CKs in the pathogenesis of infection will be discussed.
In order to present an overview of the current state of knowledge, the literature on the CMV-encoded homologs of GPCRs and CKs was reviewed.
The GPCR and CK homologs that are encoded by the CMVs represent immunomodulatory proteins with crucial roles in the pathogenesis of infection.
In light of their function as well as accessibility on the cell surface, the CMV-encoded GPCR homologs are attractive targets for the development of new anti-viral therapies.
巨细胞病毒（CMV）已发展出各种复杂的策略来操纵和逃避宿主的防御机制。在预计参与这些策略的CMV基因中，有一些基因编码细胞蛋白的模拟物，如G蛋白偶联受体（GPCR）和趋化因子（CK）。这些基因可能是在病毒与宿主的长期共同进化过程中从宿主基因组中窃取而来的。
在本报告中，将讨论CMV编码的GPCR和CK同源物在感染发病机制中的假定功能。
为了概述当前的知识状态，对关于CMV编码的GPCR和CK同源物的文献进行了综述。
CMV编码的GPCR和CK同源物代表免疫调节蛋白，在感染发病机制中起关键作用。
鉴于其功能以及在细胞表面的可及性，CMV编码的GPCR同源物是开发新型抗病毒疗法的有吸引力的靶点。
