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[扎伊德拉腹水肝癌的膜抗原]

[Membrane antigens of Zajdela ascitic hepatoma].

作者信息

Ivanov V A, Fel' V Ia, Olenov Iu M

出版信息

Tsitologiia. 1975 Jan;17(1):24-9.

PMID:164069
Abstract

The membrane antigens of Zajdela ascitic hepatoma cells were investigated. Living cells were studied by immunofluorescence method, and solublized membrane preparations by the precipitation reacting in agar gel. Testing of the tumor cells with organospecific anti-kidney serum caused a specific fluorescence of tumor cells surface. This can be due to incorporation into the antigenic structure of the Zajdela hepatoma cell membranes of at least one organospecific antigen. Treatment of the tumor cells with organospecific anti-liver serum led to specific fluorescence of tumor cells surface. In solubilizates of the tumor cells one of the three organospecific antigens peculiar for the normal liver cells, was detected.

摘要

对扎伊德拉萨腹水肝癌细胞的膜抗原进行了研究。通过免疫荧光法研究活细胞,通过琼脂凝胶中的沉淀反应研究溶解的膜制剂。用器官特异性抗肾血清检测肿瘤细胞,导致肿瘤细胞表面出现特异性荧光。这可能是由于至少一种器官特异性抗原掺入了扎伊德拉萨肝癌细胞膜的抗原结构中。用器官特异性抗肝血清处理肿瘤细胞,导致肿瘤细胞表面出现特异性荧光。在肿瘤细胞的溶解物中,检测到了正常肝细胞特有的三种器官特异性抗原之一。

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