Ivanov V A, Fel V J
Neoplasma. 1980;27(6):745-50.
Zajdela ascitic hepatoma cells were tested with the organ specific immune serum against kidney cell ghosts in the reaction of immunofluorescence. On the surface of the hepatoma cells occurred heteroorganic antigens characteristic of the membranes of intact rat kidney but never observed in their liver. Similar antigens were found in the liver of rats 1-18 days following a single injection of a hepato-carcinogen--4-dimethylaminoazobenzene but not after 4-diethylaminoazobenzene, which is a noncarcinogenic structural analogue of 4-dimethylaminoazobenzene. Noteworthy is the transient nature of this alteration in antigenic structure, since from day 21 after carcinogen application it was no longer found.
在用免疫荧光反应中针对肾细胞空壳的器官特异性免疫血清对扎伊德拉斯腹水肝癌细胞进行检测时，在肝癌细胞表面出现了完整大鼠肾脏膜所特有的异源器官抗原，但在其肝脏中从未观察到。在单次注射肝致癌物——4-二甲基氨基偶氮苯后的1至18天内，大鼠肝脏中发现了类似抗原，但在注射4-二乙氨基偶氮苯（4-二甲基氨基偶氮苯的非致癌结构类似物）后未发现。值得注意的是这种抗原结构改变的短暂性，因为在致癌物应用后第21天起就不再能发现。
