Staskal Daniele F, Diliberto Janet J, Birnbaum Linda S
UNC Curriculum in Toxicology, USA.
Toxicol Sci. 2006 Apr;90(2):309-16. doi: 10.1093/toxsci/kfj098. Epub 2006 Jan 11.
Despite its minor contribution to global polybrominated diphenyl ether (PBDE) production and usage, 2,2',4,4'-tetrabromodiphenyl ether (BDE 47) is the dominant congener found in most biotic samples in North America. The majority of public health concern has focused on potential hazardous effects resulting from exposure of infants and young children to BDE 47 because of previous studies reporting adverse developmental effects in rodent studies, in combination with human exposure estimates suggesting that nursing infants and young children have the highest exposure to BDE 47. This study was designed with two objectives: (1) to investigate the disposition of BDE 47 in infantile mice reported to be susceptible to BDE 47 and (2) to investigate the disposition and excretion of BDE 47 at various developmental stages in an attempt to further identify the mechanism responsible for rapid urinary excretion. The disposition of (14)C-BDE 47 was monitored in C57BL/6 mice following a single oral dose of BDE 47 (1 mg/kg) at different stages of development. The results show that the toxicokinetics of BDE 47 are different in developing mice than in adult mice; whereas disposition patterns are similar, concentrations of BDE 47 are higher in pups because they have a reduced capacity to excrete BDE 47. These differences lead to higher concentrations of BDE 47 at target tissues during critical windows of development.
尽管2,2',4,4'-四溴二苯醚（BDE 47）在全球多溴二苯醚（PBDE）生产和使用中所占份额较小，但它却是北美大多数生物样本中占主导地位的同系物。此前有研究报告了啮齿动物研究中的不良发育影响，同时人体暴露估计表明，哺乳期婴儿和幼儿对BDE 47的暴露量最高，因此，大多数公共卫生关注都集中在婴儿和幼儿接触BDE 47可能产生的有害影响上。本研究设定了两个目标：（1）研究BDE 47在据报道对BDE 47敏感的幼鼠体内的处置情况；（2）研究BDE 47在不同发育阶段的处置和排泄情况，以进一步确定导致其快速经尿排泄的机制。在不同发育阶段对C57BL/6小鼠单次口服剂量的BDE 47（1毫克/千克）后，监测（14）C-BDE 47的处置情况。结果表明，BDE 47在发育中小鼠体内的毒代动力学与成年小鼠不同；虽然处置模式相似，但幼鼠体内BDE 47的浓度较高，因为它们排泄BDE 47的能力较低。这些差异导致在关键发育窗口期目标组织中BDE 47的浓度较高。
