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mGluR7's lucky number.

作者信息

Conn P Jeffrey, Niswender Colleen M

机构信息

Department of Pharmacology and Center for Translational Neuropharmacology, Vanderbilt University, Nashville, TN 37232, USA.

出版信息

Proc Natl Acad Sci U S A. 2006 Jan 10;103(2):251-2. doi: 10.1073/pnas.0510051103. Epub 2006 Jan 3.

DOI:10.1073/pnas.0510051103
PMID:16407154
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1326193/
Abstract
摘要

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A selective metabotropic glutamate receptor 7 agonist: activation of receptor signaling via an allosteric site modulates stress parameters in vivo.一种选择性代谢型谷氨酸受体7激动剂：通过变构位点激活受体信号传导可调节体内应激参数。
Proc Natl Acad Sci U S A. 2005 Dec 20;102(51):18712-7. doi: 10.1073/pnas.0508063102. Epub 2005 Dec 9.
2
Metabotropic glutamate receptor subtype 7 ablation causes dysregulation of the HPA axis and increases hippocampal BDNF protein levels: implications for stress-related psychiatric disorders.代谢型谷氨酸受体7亚型缺失导致下丘脑-垂体-肾上腺轴功能失调并增加海马脑源性神经营养因子蛋白水平：对与应激相关的精神障碍的影响。
Neuropsychopharmacology. 2006 Jun;31(6):1112-22. doi: 10.1038/sj.npp.1300926.
3
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Mol Pharmacol. 2005 Dec;68(6):1793-802. doi: 10.1124/mol.105.016139. Epub 2005 Sep 9.
4
A novel selective positive allosteric modulator of metabotropic glutamate receptor subtype 5 has in vivo activity and antipsychotic-like effects in rat behavioral models.一种新型的代谢型谷氨酸受体5亚型选择性正变构调节剂在大鼠行为模型中具有体内活性和类抗精神病作用。
J Pharmacol Exp Ther. 2005 Apr;313(1):199-206. doi: 10.1124/jpet.104.079244. Epub 2004 Dec 17.
5
Allosteric modulation of G-protein coupled receptors.G蛋白偶联受体的变构调节
Eur J Pharm Sci. 2004 Mar;21(4):407-20. doi: 10.1016/j.ejps.2003.11.007.
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G protein-coupled receptor microarrays for drug discovery.
Drug Discov Today. 2003 Aug 15;8(16):755-61. doi: 10.1016/s1359-6446(03)02779-x.
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A family of highly selective allosteric modulators of the metabotropic glutamate receptor subtype 5.亲代谢型谷氨酸受体5的一类高选择性变构调节剂。
Mol Pharmacol. 2003 Sep;64(3):731-40. doi: 10.1124/mol.64.3.731.
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Unveiling the functions of presynaptic metabotropic glutamate receptors in the central nervous system.揭示中枢神经系统中突触前代谢型谷氨酸受体的功能。
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l-glutamate as a central neurotransmitter: looking back.作为中枢神经递质的L-谷氨酸：回顾
Biochem Soc Trans. 2000;28(4):297-309.