Christopherson P W, Insalaco T A, van Santen V L, Livesey L, Bourne C, Boudreaux M K
Department of Pathobiology, 166 Greene Hall, College of Veterinary Medicine, Auburn University, AL 36849-5519, USA.
Vet Pathol. 2006 Jan;43(1):78-82. doi: 10.1354/vp.43-1-78.
Glanzmann thrombasthenia (GT) is an inherited, intrinsic platelet defect characterized by a quantitative or qualitative change in the platelet glycoprotein complex IIb-IIIa (integrin alpha(IIb)beta3). The subunits are encoded by separate genes and both subunits must be expressed for a stable complex to form on the platelet surface; therefore, a defect in either gene can result in GT.
Glanzmann血小板无力症（GT）是一种遗传性的血小板内在缺陷，其特征是血小板糖蛋白复合物IIb-IIIa（整合素α(IIb)β3）发生数量或质量变化。这些亚基由不同的基因编码，两个亚基都必须表达才能在血小板表面形成稳定的复合物；因此，任一基因的缺陷都可能导致GT。
