沿着精神病易感性连续体存在神经学软体征。
The presence of neurological soft signs along the psychosis proneness continuum.
作者信息
Barkus Emma, Stirling John, Hopkins Richard, Lewis Shôn
机构信息
Neuroscience and Psychiatry Department, University of Manchester, Stopford Building, Oxford Road, Manchester M13 9PT, UK.
出版信息
Schizophr Bull. 2006 Jul;32(3):573-7. doi: 10.1093/schbul/sbj037. Epub 2006 Jan 11.
Abstract
Neurological soft signs have been observed in patients with schizophrenia and their relatives. However, it has not been considered whether the increased rates of neurological soft signs are related to measures of psychosis proneness in the general population. We tested this hypothesis in a group of normal volunteers (n = 28) who scored highly for positive schizotypy when assessed online and a control group (n = 33) who scored below the mean. Compared with the controls, high psychosis-prone individuals showed significantly higher Total and Other Soft Signs subscale scores on the Neurological Evaluation Scale. It appears that soft signs are also associated with psychosis proneness when measured in the general population, which suggests that soft signs are distributed along a continuum of risk for schizophrenia.
摘要
在精神分裂症患者及其亲属中已观察到神经软体征。然而，尚未考虑神经软体征发生率的增加是否与普通人群中精神病易感性的测量指标相关。我们在一组正常志愿者（n = 28）中检验了这一假设，这些志愿者在在线评估时阳性分裂型人格得分很高，还有一组对照组（n = 33），其得分低于平均值。与对照组相比，高精神病易感性个体在神经评估量表上的总软体征和其他软体征分量表得分显著更高。在普通人群中进行测量时，软体征似乎也与精神病易感性相关，这表明软体征沿着精神分裂症的风险连续体分布。
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2
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3
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4
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5
Value of equivocal signs in neurologic diagnosis.
Neurology. 1960 Aug;10:753-64. doi: 10.1212/wnl.10.8.753.
6
Neurological soft signs in never-treated schizophrenia.
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7
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8
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9
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10
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