Herrmann Lynn M, Baszler Timothy V, O'Rourke Katherine I, Suarez Carlos E, Bakko Marlene, Alverson Janet, Knowles Donald P
Animal Disease Research Unit, Agricultural Research Service, US Department of Agriculture, USA.
Neuroreport. 2006 Feb 6;17(2):125-9. doi: 10.1097/01.wnr.0000198430.39691.3c.
Numerous sheep with the prion gene (PRNP) that encodes for 171QQ develop scrapie, a neurodegenerative prion disease of sheep. Relatively few cases of scrapie-affected sheep with PRNP genetics that encode for 171RR, however, have been found. Using flow cytometric analysis, statistically fewer PrPc-positive microglia and monocytes were observed from sheep with 171RR PRNP genetics than from sheep with 171QQ PRNP genetics (P<0.05). One possibility for the lack of PrP(Sc) accumulation in brains and lymph nodes of scrapie-exposed sheep with 171RR PRNP genetics is because of fewer PrPc-positive myeloid-derived cells available for conversion of PrPc to PrP(Sc).
许多携带编码171QQ的朊病毒基因（PRNP）的绵羊会患上羊瘙痒病，这是一种绵羊的神经退行性朊病毒疾病。然而，相对较少发现携带编码171RR的PRNP基因且感染羊瘙痒病的绵羊病例。通过流式细胞术分析，与携带171QQ PRNP基因的绵羊相比，携带171RR PRNP基因的绵羊中，从统计学上观察到的PrPc阳性小胶质细胞和单核细胞更少（P<0.05）。对于携带171RR PRNP基因且接触过羊瘙痒病的绵羊，其大脑和淋巴结中缺乏PrP(Sc)积累的一种可能性是，可用于将PrPc转化为PrP(Sc)的PrPc阳性髓系来源细胞较少。
